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Publications

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Selected Publications

Anthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome.

Boncimino F, D’Auria L, Todorova K, van der Zanden SY, Neefjes J, Mandinova A, Missero C, Sol S.Cell Death Discov. 2025 Jan 25;11(1):24. doi: 10.1038/s41420-025-02307-0.PMID: 39863572

Patterns of Tumor-Infiltrating Lymphocytes Used to Distinguish Primary Cutaneous Squamous Cell Carcinomas That Metastasize.

Ashrafzadeh S, Foreman RK, Kalra S, Mandinova A, Asgari MM. JAMA Dermatol. 2023 Jul 1;159(7):788-790. doi:10.1001/jamadermatol. 2023.1307. PMID: 37256610

YBX1 mediates translation of oncogenic transcripts to control cell competition in AML.

Perner F, Schnoeder TM, Xiong Y, Jayavelu AK, Mashamba N, Santamaria NT, Huber N, Todorova K, Hatton C, Perner B, Eifert T, Murphy C, Hartmann M, Hoell JI, Schröder N, Brandt S, Hochhaus A, Mertens PR, Mann M, Armstrong SA, Mandinova A, Heidel FH. Leukemia. 2022 Feb;36(2):426-437. doi:10.1038/s41375-021-01393-0. Epub 2021 Aug 31. PMID: 34465866

Hyaluronic acid conjugates for topical treatment of skin cancer lesions.

Krishnan V, Peng K, Sarode A, Prakash S, Zhao Z, Filippov SK, Todorova K, Sell BR, Lujano O, Bakre S, Pusuluri A, Vogus D, Tsai KY, Mandinova A, Mitragotri S. Sci Adv. 2021 Jun 11;7(24):eabe6627. doi: 10.1126/sciadv.abe6627. Print 2021 Jun. PMID: 34117055

Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation.

Li F, Yuan CW, Xu S, Zu T, Woappi Y, Lee CAA, Abarzua P, Wells M, Ramsey MR, Frank NY, Wu X, Mandinova A, Frank MH, Lian CG, Murphy GF. J Invest Dermatol. 2020 Jun; 140(6):1266-1275.e3. Doi: 10.1016/j.jid.2019.10.016. Epub 2019 Dec 11. PMID: 31837302

Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.

El-Naggar AM, Somasekharan SP, Wang Y, Cheng H, Negri GL, Pan M, Wang XQ, Delaidelli A, Rafn B, Cran J, Zhang F, Zhang H, Colborne S, Gleave M, Mandinova A, Kedersha N, Hughes CS, Surdez D, Delattre O, Wang Y, Huntsman DG, Morin GB, Sorensen PH. EMBO Rep. 2019 Dec 5;20(12):e48375. doi: 10.15252/embr.201948375. Epub 2019 Oct 31. PMID: 31668005

The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.

Kwon E, Todorova K, Wang J, Horos R, Lee KK, Neel VA, Negri GL, Sorensen PH, Lee SW, Hentze MW, Mandinova A. Nat Commun. 2018 Apr 30;9(1):1734. doi: 10.1038/s41467-018-04092-0. PMID: 29712925

GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death.

Sieber J, Wieder N, Clark A, Reitberger M, Matan S, Schoenfelder J, Zhang J, Mandinova A, Bittker JA, Gutierrez J, Aygün O, Udeshi N, Carr S, Mundel P, Jehle AW, Greka A. Cell Chem Biol. 2018 Feb 15;25(2):175-184.e4. doi: 10.1016/j.chembiol.2017.11.006. Epub 2017 Dec 14. PMID: 29249695

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.

Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R. Science. 2017 Sep 15;357(6356):1156-1160. doi: 10.1126/science.aah5043. PMID: 28912244

Emerging roles of p53 and other tumour-suppressor genes in immune regulation.

Muñoz-Fontela C, Mandinova A, Aaronson SA, Lee SW. Nat Rev Immunol. 2016 Dec;16(12):741-750. doi: 10.1038/nri.2016.99. Epub 2016 Sep 26. PMID: 27667712

Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling.

Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW. Cell Rep. 2016 Jun 28;16(1):28-36. doi: 10.1016/j.celrep.2016.05.071. Epub 2016 Jun 16. PMID: 27320923

Sustained Akt Activity Is Required to Maintain Cell Viability in Seborrheic Keratosis, a Benign Epithelial Tumor.

Neel VA, Todorova K, Wang J, Kwon E, Kang M, Liu Q, Gray N, Lee SW, Mandinova A. J Invest Dermatol. 2016 Mar;136(3):696-705. doi: 10.1016/j.jid.2015.12.023. Epub 2015 Dec 29. PMID: 26739095

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.

Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW. Science. 2015 Jul 31;349(6247):1261669. doi: 10.1126/science.1261669. PMID: 26228159

Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling.

Zhu Z, Todorova K, Lee KK, Wang J, Kwon E, Kehayov I, Kim HG, Kolev V, Dotto GP, Lee SW, Mandinova A. Cancer Res. 2014 Apr 1;74(7):2082-93. doi: 10.1158/0008-5472.CAN-12-0452. Epub 2014 Feb 13. PMID: 24525741

CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress.

Namba T, Tian F, Chu K, Hwang SY, Yoon KW, Byun S, Hiraki M, Mandinova A, Lee SW. Cell Rep. 2013 Oct 31;5(2):331-9. doi: 10.1016/j.celrep.2013.09.020. Epub 2013 Oct 17. PMID: 24139803

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.

Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW. Nat Commun. 2013;4:2189. doi: 10.1038/ncomms3189. PMID: 23877263

Expression of the p53 target CDIP correlates with sensitivity to TNFα-induced apoptosis in cancer cells.

Brown-Endres L, Schoenfeld D, Tian F, Kim HG, Namba T, Muñoz-Fontela C, Mandinova A, Aaronson SA, Lee SW. Cancer Res. 2012 May 1;72(9):2373-82. doi: 10.1158/0008-5472.CAN-11-3369. PMID: 22549949

A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.

Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin MJ, Ostano P, Dummer R, Brissette JL, Dotto GP. J Clin Invest. 2009 Oct;119(10):3127-37. doi: 10.1172/JCI38543. PMID: 19729838

A small molecule that binds Hedgehog and blocks its signaling in human cells.

Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142. Epub 2009 Jan 18. PMID: 19151731

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP. Nat Cell Biol. 2008 Aug;10(8):902-11. doi: 10.1038/ncb1750. Epub 2008 Jul 6. PMID: 18604200

The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response.

Mandinova A, Lefort K, Tommasi di Vignano A, Stonely W, Ostano P, Chiorino G, Iwaki H, Nakanishi J, Dotto GP. EMBO J. 2008 Apr 23;27(8):1243-54. doi: 10.1038/emboj.2008.45. Epub 2008 Apr 3. PMID: 18388864

CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.

Brown L, Ongusaha PP, Kim HG, Nuti S, Mandinova A, Lee JW, Khosravi-Far R, Aaronson SA, Lee SW. EMBO J. 2007 Jul 25;26(14):3410-22. doi: 10.1038/sj.emboj.7601779. Epub 2007 Jun 28. PMID: 17599062